Hard to believe, but those who advocate negotiations under such circumstances are known as "realists." A real realist would realize that Syria and Iran are only likely to accommodate the U.S. when they're afraid of us. Iran played a constructive role in Afghanistan after the fall of the Taliban in 2001, and Syria scuttled out of Lebanon in 2005 under strong pressure. Now, however, we would be bargaining from a position of weakness, not strength.
We are on the verge of defeat in Iraq. Our enemies have no interest in bailing us out, unless the cost is prohibitive.